SLU-PP-332
ERRα agonist for exercise mimetic and endurance research
Key Research Areas
Researched for exercise mimetic effects
Studied for endurance enhancement mechanisms
Investigated for metabolic regulation
What is SLU-PP-332?
SLU-PP-332 is a synthetic small molecule (not technically a peptide) developed at Saint Louis University. It acts as an agonist of estrogen-related receptor alpha (ERRα), a nuclear receptor that plays a crucial role in energy metabolism and mitochondrial function. ERRα is naturally activated by exercise, making SLU-PP-332 an "exercise mimetic" that may replicate some metabolic benefits of physical activity.
What It's Used For
Research applications focus on understanding exercise physiology at the molecular level, investigating endurance enhancement mechanisms, studying metabolic diseases and obesity, exploring potential treatments for conditions where exercise is difficult (muscle wasting, mobility limitations), and examining the role of ERRα in various tissues including muscle, heart, and adipose tissue.
How It Works (Mechanisms Explained)
SLU-PP-332 activates ERRα, which in turn regulates the expression of genes involved in fatty acid oxidation, oxidative phosphorylation, and mitochondrial biogenesis. This leads to increased fat burning and improved endurance capacity in research models. The compound essentially tricks cells into thinking they are exercising, activating metabolic adaptations typically seen with physical training. It particularly affects slow-twitch muscle fibers, which are crucial for endurance.
Common Research Stacks
As a relatively new research compound, SLU-PP-332 is typically studied in isolation to understand its specific effects. Future research may explore combinations with other metabolic modulators or actual exercise to see if effects are additive or synergistic.
Common Beginner Mistakes
Expecting it to replace actual exercise (research suggests it may complement but not fully replace physical activity benefits), not understanding that it is a small molecule rather than a peptide, limited availability and lack of long-term safety data, and unrealistic expectations about the magnitude or speed of effects.
Reconstitution Basics
SLU-PP-332 is a small molecule typically provided in powder form for research purposes. It is usually dissolved in appropriate solvents (such as DMSO or PEG) for administration in research settings. Unlike peptides, it does not require bacteriostatic water reconstitution. Storage and handling instructions vary by supplier, so always follow specific product guidelines.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.