Key Research Areas
Researched for cellular energy production
Studied for DNA repair mechanisms
Investigated for anti-aging pathways
What is NAD+?
NAD+ is not a peptide but a dinucleotide coenzyme essential for life. It exists in two forms: NAD+ (oxidized) and NADH (reduced), shuttling electrons in metabolic reactions. NAD+ levels naturally decline with age, and this decline is associated with various age-related conditions. Supplementation aims to restore youthful NAD+ levels.
What It's Used For
Research focuses on cellular metabolism studies, sirtuin activation (longevity genes), DNA repair mechanisms, mitochondrial function, neurodegenerative disease research, and metabolic health. NAD+ is central to hundreds of enzymatic reactions in the body.
How It Works (Mechanisms Explained)
NAD+ is a substrate for sirtuins (SIRT1-7), enzymes that regulate cellular health, metabolism, and longevity. It's also required by PARPs (poly ADP-ribose polymerases) for DNA repair. Additionally, NAD+ is essential for the electron transport chain in mitochondria, directly impacting cellular energy (ATP) production. Declining NAD+ levels impair all these critical functions.
Common Research Stacks
NAD+ research often involves combination with precursors like NMN or NR, resveratrol (sirtuin activator), or other longevity compounds. Some protocols study NAD+ alongside peptides targeting mitochondrial function like SS-31 or MOTS-c.
Common Beginner Mistakes
Confusing NAD+ with its precursors (NMN, NR, niacin - they work differently), not understanding that direct NAD+ has bioavailability challenges, expecting immediate anti-aging effects, and not considering the various administration routes (IV, subcutaneous, sublingual).
Reconstitution Basics
NAD+ at 500mg is typically provided for subcutaneous or IV administration. Reconstitute with bacteriostatic water or sterile saline depending on the administration route. For subcutaneous use, standard peptide reconstitution applies. NAD+ injections may cause flushing and should be administered slowly. Refrigerate after reconstitution.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.