MOTS-c
Mitochondrial-derived peptide for metabolic and longevity research
Key Research Areas
Researched for mitochondrial function support
Studied for metabolic regulation effects
Investigated for exercise mimetic properties
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial DNA. Unlike most peptides which are encoded by nuclear DNA, MOTS-c originates from the mitochondria themselves, making it part of an emerging class of mitochondrial-derived peptides (MDPs). It was discovered relatively recently and has garnered significant research interest due to its apparent role in metabolic homeostasis.
What It's Used For
Research applications focus on metabolic regulation studies, insulin sensitivity investigations, exercise physiology research, aging and longevity studies, and cellular energy metabolism. MOTS-c has been called an "exercise mimetic" in research contexts due to its apparent ability to activate similar metabolic pathways as physical exercise.
How It Works (Mechanisms Explained)
MOTS-c appears to work primarily through activation of the AMPK (AMP-activated protein kinase) pathway, which is a master regulator of cellular energy balance. When AMPK is activated, it promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while inhibiting energy-consuming processes. MOTS-c also influences the folate-methionine cycle, affecting cellular metabolism at a fundamental level. Its mitochondrial origin suggests it may serve as a retrograde signal from mitochondria to the nucleus.
Common Research Stacks
In research settings, MOTS-c is sometimes studied alongside other longevity-focused compounds or mitochondrial support agents. Its unique mechanism makes it distinct from most other peptides, so it is often researched independently to better understand its specific effects.
Common Beginner Mistakes
Not understanding its unique mitochondrial origin and mechanism, expecting immediate visible results (effects are often at the cellular/metabolic level), improper storage degrading the peptide, confusing research findings with proven therapeutic applications, and not maintaining consistent administration schedules in research protocols.
Reconstitution Basics
MOTS-c comes as a lyophilized powder requiring reconstitution with bacteriostatic water. Use standard sterile technique, inject water slowly along the vial wall, and swirl gently to dissolve. Once reconstituted, store refrigerated and use within 28 days. Some research protocols suggest subcutaneous administration.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.