Key Research Areas
Researched for anti-inflammatory effects
Studied for gut health applications
Investigated for skin healing properties
What is KPV?
KPV (Lysine-Proline-Valine) is a tripeptide fragment derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). While α-MSH is known for its effects on skin pigmentation, the KPV fragment retains the anti-inflammatory properties without causing changes in melanin production. This makes it an attractive research compound for studying inflammation modulation.
What It's Used For
Research applications focus on inflammatory conditions, particularly gastrointestinal inflammation (inflammatory bowel disease models), skin inflammation and wound healing, immune system modulation, and antimicrobial activity. KPV has shown promise in research for conditions where inflammation plays a central role.
How It Works (Mechanisms Explained)
KPV exerts its anti-inflammatory effects through multiple mechanisms. It inhibits the activation of NF-κB, a key transcription factor that promotes inflammation. It also reduces the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, KPV can enter cells and directly interact with inflammatory signaling pathways. Its antimicrobial properties add another layer of benefit in wound healing contexts.
Common Research Stacks
In research settings, KPV is often studied alongside other gut-health compounds or anti-inflammatory agents. For skin applications, it may be combined with other regenerative peptides like GHK-Cu. Its unique mechanism makes it complementary to many other therapeutic approaches.
Common Beginner Mistakes
Not understanding the difference between KPV and full α-MSH (KPV does not cause tanning), expecting immediate visible results (anti-inflammatory effects may not be immediately apparent), improper storage degrading the peptide, and using it without understanding the underlying inflammatory condition being addressed.
Reconstitution Basics
KPV comes as a lyophilized powder requiring reconstitution with bacteriostatic water. Use standard sterile technique, add water slowly along the vial wall, and swirl gently to dissolve. Once reconstituted, refrigerate and use within 28 days. KPV can be administered subcutaneously, and some research explores oral or topical delivery for specific applications.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.