Kisspeptin
Reproductive hormone regulator for endocrine research
Key Research Areas
Researched for reproductive hormone regulation
Studied for GnRH and LH stimulation
Investigated for fertility applications
What is Kisspeptin?
Kisspeptin is a peptide encoded by the KISS1 gene, discovered initially for its role in suppressing cancer metastasis (hence "metastin"). It was later found to be essential for puberty onset and reproductive function. Kisspeptin neurons in the hypothalamus control the release of gonadotropin-releasing hormone (GnRH).
What It's Used For
Research applications include fertility studies, hypogonadism investigations, puberty timing research, testosterone regulation studies, and potential IVF applications. Kisspeptin offers a more physiological approach to stimulating reproductive hormones compared to direct hormone administration.
How It Works (Mechanisms Explained)
Kisspeptin binds to GPR54 (KISS1R) receptors on GnRH neurons in the hypothalamus. This stimulates GnRH release, which then triggers the pituitary to release LH and FSH. The result is increased testosterone (in males) or estrogen/progesterone (in females). This cascade makes kisspeptin a master regulator of reproductive function.
Common Research Stacks
Kisspeptin is typically researched as a standalone to understand its effects on the HPG axis. Some research examines it alongside other fertility-related compounds or compares it to traditional hormone stimulation methods.
Common Beginner Mistakes
Not understanding its systemic hormonal effects, using without proper hormonal monitoring, expecting it to work like testosterone replacement (it stimulates natural production instead), and not accounting for individual variation in response.
Reconstitution Basics
Reconstitute kisspeptin with bacteriostatic water using sterile technique. For 5mg, adding 2ml provides 250mcg per 0.1ml. Research protocols vary in timing based on the specific study goals. Kisspeptin has a relatively short half-life, so timing of administration is important. Refrigerate after reconstitution.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.