Cagrilintide
Long-acting amylin analogue for metabolic research
Key Research Areas
Researched for appetite regulation
Studied for glucose metabolism
Investigated for weight management mechanisms
What is Cagrilintide?
Cagrilintide is an acylated synthetic analogue of amylin, a 37-amino acid peptide hormone produced by pancreatic beta cells. The modifications give cagrilintide a much longer half-life than native amylin, allowing for less frequent dosing. It is being developed in combination with semaglutide (CagriSema) for enhanced metabolic effects.
What It's Used For
Research applications focus on appetite and satiety studies, gastric emptying regulation, glucose metabolism, weight management research, and potential diabetes applications. Cagrilintide addresses the amylin pathway, which is complementary to GLP-1 based approaches.
How It Works (Mechanisms Explained)
Amylin works alongside insulin to regulate glucose. Cagrilintide activates amylin receptors (combinations of calcitonin receptor with RAMPs), slowing gastric emptying, reducing glucagon secretion, and promoting satiety through central nervous system effects. This multi-faceted action helps regulate both food intake and glucose levels.
Common Research Stacks
Cagrilintide is being researched in combination with semaglutide (a GLP-1 agonist) as CagriSema, showing enhanced weight loss effects compared to either alone. Research may also explore combinations with other metabolic compounds.
Common Beginner Mistakes
Confusing it with other metabolic peptides like GLP-1 agonists (different mechanism), not understanding its investigational status, improper dose titration, and not accounting for its effects on gastric emptying when considering other medications or supplements.
Reconstitution Basics
Cagrilintide comes as lyophilized powder requiring reconstitution with bacteriostatic water. Use standard sterile technique, add water slowly, and swirl gently. Due to its long-acting nature, research protocols typically involve weekly rather than daily administration. Refrigerate after reconstitution.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.