5-Amino-1MQ
NNMT inhibitor for metabolic and fat loss research
Key Research Areas
Researched for fat cell metabolism effects
Studied for NAD+ pathway support
Investigated for metabolic rate enhancement
What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is technically a small molecule rather than a peptide, but it is often discussed alongside peptides in metabolic research contexts. It functions as an inhibitor of NNMT, an enzyme that is highly expressed in fat tissue and plays a role in cellular energy regulation. By blocking NNMT, 5-Amino-1MQ may influence how the body processes and stores fat.
What It's Used For
Research applications focus on obesity and fat metabolism studies, NAD+ (nicotinamide adenine dinucleotide) pathway research, metabolic syndrome investigations, energy expenditure studies, and potential anti-aging applications related to NAD+ preservation. It represents a novel approach to metabolic research by targeting a specific enzyme.
How It Works (Mechanisms Explained)
NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N-methyl-nicotinamide. This process depletes SAM (S-adenosyl methionine), a universal methyl donor, and reduces the availability of nicotinamide for NAD+ synthesis. By inhibiting NNMT, 5-Amino-1MQ may increase SAM and nicotinamide levels, potentially boosting NAD+ production. Higher NAD+ levels are associated with improved mitochondrial function and cellular energy. Additionally, NNMT inhibition in fat cells appears to promote a shift toward a more metabolically active phenotype.
Common Research Stacks
In research contexts, 5-Amino-1MQ may be studied alongside other metabolic interventions or NAD+ precursors. Some research protocols examine its effects in combination with lifestyle factors like diet and exercise. Its unique mechanism makes it interesting for combination studies with other metabolic compounds.
Common Beginner Mistakes
Confusing it with peptides (it's technically a small molecule), expecting it to replace diet and exercise for weight management, not understanding the role of NNMT and NAD+ in metabolism, improper sourcing leading to quality issues, and unrealistic expectations about the speed or magnitude of effects.
Reconstitution Basics
5-Amino-1MQ is typically available in capsule or powder form for oral administration, unlike most peptides which require injection. If using powder, it is usually dissolved in water or taken directly. No reconstitution with bacteriostatic water is typically required. Store in a cool, dry place away from light. Follow specific product instructions for dosing and administration.
Educational Disclaimer
This content is for educational purposes only and is not intended as medical advice. Research peptides are not approved for human use by regulatory bodies like the FDA. Always consult qualified healthcare professionals before making any health-related decisions.